Chemical name: N - [2 - [4 - [[[(cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] - 2-methoxy-5-chlorobenzamide. Chemical structure formula: molecular formula: C 23H 28ClN 3O 5S molecular weight: 494.01
This product is white.
As a generic drug supplier in China,Feiyue Pharmaceutical can provide finished drugs such as Glibenclamide Tablets
FEIYUE recruits agents worldwide, we can provide complete registration documents.
It is applicable to patients with mild to moderate non insulin dependent diabetes who are dissatisfied with the efficacy of diet control alone β The islet cells can secrete insulin to a certain extent without serious complications.
Usage and dosage
Take 2.5 mg (1 tablet) orally, once before breakfast or before breakfast and lunch, 1.25 mg (half tablet) for mild patients, three times a day, three times before meals, and 2.5 mg (1 tablet) daily after 7 days. The general dosage is 5-10mg (2-4 tablets) per day, and the maximum dosage is not more than 15mg (6 tablets) per day.
1. May have diarrhea, nausea, vomiting, headache, stomachache or discomfort; 2. Rarely, there is rash; 3. The rare and serious ones include jaundice, liver function damage, bone marrow suppression, granulocytopenia (manifested as pharyngalgia, fever, infection), thrombocytopenia (manifested as hemorrhage, purpura), etc.taboo
The following conditions should be prohibited: 1. Type I diabetes patients; 2. Type II diabetic patients are accompanied by ketoacidosis, coma, severe burns, infection, trauma, major surgery and other stress conditions; 3. Liver and kidney dysfunction; 4. People who are allergic to sulfa drugs; 5. Patients with leukopenia.
matters needing attention
The following cases should be used with caution: physical weakness, high fever, abnormal liver or kidney function, nausea and vomiting, hyperthyroidism, and the elderly. 2. Blood glucose, urine sugar, urine ketone body, urine protein, liver and kidney function should be measured regularly during the medication, and ophthalmic examination should be carried out.
1. When taken with alcohol, it can cause abdominal colic, nausea, vomiting, headache, facial flushing and hypoglycemia. 2. and β－ The combination of receptor blockers can increase the risk of hypoglycemia and mask the symptoms of hypoglycemia, such as faster pulse rate and higher blood pressure; Small volume selectivity β Receptor blockers such as atenolol and metoprolol are less likely to cause this condition. 3. Chloramphenicol, guanethidine, insulin, monoamine oxidase inhibitor, balthasone, hydroxybalthasone, probenecid, salicylate, sulfonamide and this product can be used together to strengthen the hypoglycemic effect. 4. Adrenocorticosteroids, epinephrine, phenytoin sodium, thiazide diuretics, and thyroxine can increase blood glucose levels. When used with this drug, the dosage of this drug may need to be increased. 5. When coumarin anticoagulants are used with this kind of drug, the plasma concentrations of each other increase at first, but then decrease, so it is necessary to adjust the dosage of both.
Pharmacology and toxicology
This product is a hypoglycemic drug. 1. Stimulate pancreatic islets β Cells secrete insulin, and the precondition is islet β Cells also have certain functions of synthesizing and secreting insulin; 2. By increasing the level of insulin in the portal vein or acting directly on the liver, the liver glycogen decomposition and glycogenosis are inhibited, and the glucose production and output of the liver are reduced; 3. It may also increase the sensitivity of extrapancreatic tissue to insulin and the utilization of glucose (mainly through the post-receptor effect). Therefore, the overall effect is to reduce fasting blood glucose and postprandial blood glucose.
The oral absorption is fast, and the protein binding rate is very high, which is 95%. The blood drug concentration reaches the peak in 2-5 hours after oral administration, and it lasts for 24 hours. The half-life is 10 hours. It is metabolized in the liver and excreted by the liver and kidney by about 50% respectively.
Keep in airtight condition.