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Kanamycin for Injection

February 01,2023


This product is white or white-like powder.


This product is suitable for serious infections caused by sensitive enterobacteriaceae bacteria such as Escherichia coli, Klebsiella, Proteus, Enterobacter aerogenes, Shigella, etc., such as pneumonia, septicemia, abdominal infection, etc., and often needs to be combined with other antibacterial drugs.

As a generic drug supplier in China, Feiyue Pharmaceutical can provide finished drugs such as Kanamycin for Injection

Packaging: 10ml tubular vial with filp-off, 1's/box, 10's/box, 50's/box

FEIYUE recruits agents worldwide, we can provide complete registration documents.


1. Adults usually use intramuscular injection or intravenous drip, 0.5g at a time, once every 12 hours; Or according to the weight of 7.5mg/kg, once every 12 hours, the daily dosage of adults should not exceed 1.5g, and the course of treatment should not exceed 14 days. The dosage of patients over 50 years old should be reduced appropriately. 2. Children usually use intramuscular injection or intravenous drip, which is 15 ~ 25 mg/kg per day according to their body weight and given twice. 3. Kanamycin sulfate 0.25% solution can be used as washing liquid. 0.1% solution can also be used for gas inhalation. 2.5% injection can be used for intraperitoneal administration. 4. Dosage for renal dysfunction: creatinine clearance rate is 50 ~ 90 mg/min, 60% ~ 90% of the normal dosage, once every 12 hours (the normal dosage is 7.5mg/kg, once every 12 hours); The creatinine clearance rate is 10 ~ 50ml/min, with 30% ~ 70% of the normal dose, once every 12 ~ 18 hours; The creatinine clearance rate [10mg/ min is 20% ~ 30% of the normal dose, once every 24 ~ 48 hours.

adverse effect

1. Hearing loss, tinnitus or ear fullness may occur during the course of treatment, which is caused by affecting the cochlear nerve. A small number of patients, especially those with renal dysfunction, can occur after stopping taking drugs, which should be paid attention to. Vertigo and unsteady gait may occur when vestibular nerve function is affected, but it is rare.

2. Nephrotoxic reactions such as hematuria, decreased urination frequency or urine volume, loss of appetite, nausea, vomiting and extreme thirst may occur.

3. Occasionally there may be neuromuscular block such as dyspnea, lethargy or weakness.

4. Other adverse reactions include headache, rash, drug fever, numbness around the mouth, leukopenia, eosinophilia and local pain after intramuscular injection.


Those who have allergic history to this product or other aminoglycoside drugs are prohibited.

matters need attention

1. Patients who are allergic to aminoglycoside antibiotics, such as streptomycin, gentamicin and amikacin, may also be allergic to this product. 2. The following tests should be paid attention to during medication: (1) Routine urine examination and renal function determination to prevent serious nephrotoxicity. (2) Auditory examination or audiogram, especially high-frequency audiometry, is more important for the elderly. 3. Blood drug concentration should be monitored when conditions permit, especially for newborns, the elderly and patients with renal dysfunction. When given once every 12 hours, the peak concentration of the drug in blood should be kept at 15 ~ 30μ g/ml, and the valley concentration should be kept at 5 ~ 10μ g/ml. The peak plasma concentration should be kept at 56 ~ 64 μ g/ml and the trough concentration should be kept at [1μg/ml. 4. This product should be used with caution in the following situations: (1) dehydration can increase the blood drug concentration and increase the possibility of toxic reactions. (2) the eighth pair of cranial nerve damage, because this product can cause damage to the auditory nerve and vestibular function. (3) myasthenia gravis or Parkinson's disease, because this product can cause neuromuscular block, leading to skeletal muscle weakness. (4) Renal function damage, because this product can cause nephrotoxicity. 5. Interference to diagnosis: It can increase the measured values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum bilirubin concentration and serum lactate dehydrogenase concentration; The measured values of blood calcium, magnesium, potassium and sodium may decrease. 6. When aminoglycosides are mixed with β -lactams (cephalosporins and penicillins), they can cause mutual inactivation. When kanamycin is used in combination with the above antibiotics, it must be dripped in different bottles. Kanamycin should not be dripped with other drugs in the same bottle. 7. This product may cause ototoxicity and nephrotoxicity, so it is not suitable for long-term treatment (such as mycosis), and the course of treatment usually does not exceed 14 days.

drug interaction

1. It can increase ototoxicity, nephrotoxicity and neuromuscular blockade if it is combined with other aminoglycosides or applied locally or systemically. 2. Combined with neuromuscular blocking drugs, it can aggravate neuromuscular blocking effect, leading to muscle weakness and respiratory depression. 3. Combination with capreomycin, cisplatin, itaconic acid, furosemide or vancomycin (or norvancomycin), or continuous local or systemic application may increase ototoxicity and nephrotoxicity. 4. Local or systemic use with cefthiophene or cefazolin may increase nephrotoxicity. 5. Combined with polymyxin injection, or continuous local or systemic application can increase nephrotoxicity and neuromuscular block. 6. Other nephrotoxic drugs and ototoxic drugs should not be combined with this product or applied successively to avoid aggravating nephrotoxicity or ototoxicity. null


Due to the lack of specific antagonists, when kanamycin is excessive or causes toxic reactions, symptomatic therapy and supportive therapy are mainly used, and a lot of water is supplemented at the same time. Hemodialysis or peritoneal dialysis is helpful to remove kanamycin from blood.

store up

Sealed and stored in a dry place.