The active ingredient of this product: Niergoline
Chemical name: 10 α- Methoxy-1,6-dimethylergoline-8 β- Methanol-5-bromononicotinic acid ester
Molecular formula: C24H26BrN3O3
Molecular weight: 484.39
Excipients: lactose, phosphoric acid
As a generic drug supplier in China, Feiyue Pharmaceutical can provide finished drugs such as Nicergoline for Injection
Packaging: 4mg ; 8mg
FEIYUE recruits agents worldwide, we can provide complete registration documents.
This product is a white freeze-dried block.
Usage and dosage
Intramuscular injection: 2-4mg each time, twice a day.
Intravenous infusion: 4-8mg each time, dissolved in 100ml of physiological saline or glucose injection, intravenous infusion 1-2 times a day.
Arterial injection: Dissolve 4mg into 10ml of physiological saline and slowly inject for 2 minutes each time.
No serious adverse reactions have been reported. May include hypotension, dizziness, stomach pain, hot flashes, facial flushing, drowsiness, insomnia, etc. In clinical trials, an increase in uric acid concentration in the blood can be observed, but this phenomenon is not related to the dosage and duration of administration.
This product is prohibited in the following situations:
Individuals who are allergic to nimergoline;
Recent myocardial infarction, acute bleeding, hypotension, severe bradycardia, orthostatic regulatory dysfunction, and bleeding tendency.
matters needing attention
Occasionally, temporary orthostatic hypotension and dizziness occur, and the patient should be allowed to lie flat for a few minutes after injection. It should be used under the guidance of a doctor. Usually, this product has no effect on blood pressure at the therapeutic dose, but may gradually lower blood pressure in sensitive patients. Be careful to use it in patients with hyperuricemia or patients with gout history. Patients with renal insufficiency should reduce their dosage.
Keep out of reach of children!
Medication for pregnant and lactating women
Pregnant women generally should not use it, and when necessary, the pros and cons should be weighed. This medicine is not suitable for lactating women.
Prohibited for children.
Niergoline may enhance the effect of antihypertensive drugs, as it is metabolized through CYTP450 2D6, it cannot be ruled out that it interacts with drugs that pass through the same metabolic pathway.
High doses of nimergoline may cause a temporary decrease in blood pressure and generally do not require treatment. Simply lie down and rest for a few minutes. Rare cases include insufficient blood supply to the brain and heart, and it is recommended to administer sympathetic drugs under continuous blood pressure monitoring.
Pharmacology and Toxicology
This product is a semi synthetic ergot alkaloid derivative with α- Receptor blockade and vasodilation. It can strengthen the energy metabolism of brain cells and increase the utilization of oxygen and glucose. Promote the conversion of the neurotransmitter dopamine, increase nerve conduction, enhance brain protein synthesis, and improve brain function.
The toxicity test did not show that nimergoline has teratogenic effects.
Keep away from light and seal in a cool place (not exceeding 20 ℃).
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